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MRC = 0 (n = 7)
|
MRC ≥ 1 (n = 38)
|
|---|
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Demographic characteristics
| | |
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Age
|
50 ± 10
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51 ± 11
|
|
Sex (M/F)
|
4/3
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13/25
|
|
BMI (kg/m
2
)
|
36 ± 5
|
44 ± 9*
|
|
Smoking history
| | |
|
Pack-years
|
10 ± 16
|
10 ± 17
|
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PFTs
| | |
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FEV1,% pred
|
101 ± 16
|
86 ± 17*
|
|
VC,% pred
|
103 ± 15
|
90 ± 20
|
|
FEV1/VC
|
0.78 ± 0.05
|
0.77 ± 0.11
|
|
FRC,% pred
|
100 ± 16
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91 ± 25
|
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ERV,% pred
|
91 ± 32
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50 ± 31**
|
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TLC,% pred
|
101 ± 11
|
97 ± 17
|
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DLCO,% pred
|
86 ± 18
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83 ± 19
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Arterial blood gases
| | |
|
PaO2 (mmHg)
|
99 ± 24
|
88 ± 14
|
|
PaCO2 (mmHg)
|
39 ± 4
|
39 ± 4
|
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6-minute walk test
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6-minute walk distance (m)
|
524 ± 72
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401 ± 107**
|
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SpO2 at rest (%)
|
98 ± 2
|
97 ± 2
|
|
SpO2 after exertion (%)
|
94 ± 2
|
96 ± 2
|
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Borg score at res
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0.1 ± 0.4
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1.1 ± 1.6
|
|
Borg score after 6MWT
|
3.9 ± 3
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5.7 ± 2.1
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Biological parameters
| | |
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Hemoglobin (g/dL)
|
14.8 ± 1,3
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13.7 ± 1,5*
|
|
NT pro-BNP (pg/mL)
|
97 ± 199
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121 ± 301
|
|
CRP (mg/L)
|
5 ± 4,9
|
9.1 ± 7,4
|
|
Triglyceride (mmol/L)
|
1.9 ± 0,9
|
1.5 ± 0,8
|
|
Total cholesterol (mmol/L)
|
5.4 ± 1
|
4.7 ± 1
|
|
Fasting glucose (mmol/L)
|
5.3 ± 0,8
|
7.8 ± 3,3
|
|
Hba1c (%)
|
5.7 ± 0,6
|
6.8 ± 1,6
|
- Data are expressed as number (%) or mean ± SD; *p value < 0.05, **p value < 0.01.
- FEV1: expiratory volume in one second, pred: predicted value, VC: vital capacity, FRC: functional residual capacity, ERV: expiratory reserve volume, TLC: total lung capacity, DLCO: carbon monoxide diffusing capacity of the lung, NT pro-BNP: N-terminal pro brain natriuretic peptide, CRP: serum C reactive protein, HbA1c: glycated hemoglobin.
- Normal biological parameters values were based on the normal values for our laboratory: fasting glucose: 3.3 to 6.1 mmol/L; HbA1c: 4 to 6%; total cholesterol: 3 to 5.2 mmol/L; triglycerides: 0.3 to 1.7 mmol/L; NT-pro BNP < 300 pg/mL; CRP < 10 mg/L. Anemia was defined as hemoglobin level < 13 g/dL in men and 12 g/dL in women.
