Correlation between sestrin2 expression and airway remodeling in COPD

BMC Pulmonary Medicine

Table 2 Serum sestrin2 and MMP9 concentrations and quantitative CT measurements in the total subjects

Test index	Control group(n = 62)	COPD group(n = 62)	P value
Serum assay
Sestrin2(ng/ml)	5.00 (3.93)	8.61 (2.89)	< 0.001^b
MMP9(ng/ml)	993.02 (421.30)	2125.65 (840.81)	< 0.001^a
Airway parameters on chest CT
Ai8(mm)	4.45 (0.28)	5.51 (0.64)	< 0.001^a
A_O (mm²)	28.05 (2.50)	38.72 (7.41)	< 0.001^a
WA% (%)	70.53 (3.01)	78.31 (3.73)	< 0.001^a
RWT	0.23 (0.11)	0.27 (0.02)	< 0.001^a

Notes: Data are presented as means (standard deviation) or median (interquartile range). P-values were calculated by statistical analysis of variable
Abbreviations: CT computed tomography, MMP9 matrix metalloproteinases 9, Ai8 Square root of the wall area at an internal airway area of 8 mm², A_O total airway area, WA% wall area percentage, RWT the ratio of airway wall thickness to overall diameter, ^at-test ^bMann-Whitney U test

ISSN: 1471-2466